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*;Outline;? Repeatedly image the location(s) of one or more specific population of cells of interest and determine cell quantity at all locations in living subjects ? Repeatedly image the “status” of populations of cells in living subjects including potential interactions with other cells ? Do not significantly perturb the cells while repeatedly imaging them ? Allow smooth transition from pre-clinical to clinical models ;Methods for Imaging Therapeutic Cells in Living Subjects ;Direct Labeling Strategies;111In CIK SPECT 24 hours 42 hours ;Reporter Gene Based Therapeutic Cell Imaging; ;Repo