Chapter 7 抗原呈递细胞教学案例.pptVIP

Chapter 7 APC; Antigen presenting cell (APC) Definition APC is a cell that displays peptide fragment of protein antigens, in association with MHC molecules, on its surface and activates antigen-specific T cells. In addition to displaying peptide-MHC complexes, APCs must also express costimulatory molecules to activate T lymphocytes optimally. ;T cells do not recognise native antigens;;Non-professional APC ： 在某些活性分子刺激下能被诱导表达MHC-II类分子并能处理和提呈抗原的细胞 。包括：内皮细胞；纤维母细胞；上皮及间皮细胞；嗜酸性粒细胞等。抗原提呈能力弱。 广义APC：指能加工处理抗原并以抗原肽-MHC分子复合物的形式提呈抗原信息的所有细胞。 ;Classification and distribution ①DC in lymphoid tiss