具有协同抗耐药真菌活性的天然小分子化合物研究进展.pdfVIP

药学学报 Acta Pharmaceutica Sinica 2014, 49 (8): 1097−1104 ·1097 · 1, 2 1* 1* 谭善伦 , 张大志 , 姜远英 (1. 中国人民解放军第二军医大学药学院, 上海 200433; 2. 福建中医药大学药学院, 福建 福州 350112) : 近几十年来, 一方面深部真菌感染发生率呈显著上升趋势, 另一方面真菌耐药性包括天然耐药和获 得性耐药成为侵袭性真菌感染治疗失败的主要原因之一。现有抗真菌药物品种数量有限且联合应用协同作用不 明显, 寻找新的小分子化合物作为已有抗真菌药物的增效剂来发挥协同作用, 可成为治疗侵袭性真菌感染的新 策略。本文结合本课题组的研究工作及国内外报道的具有协同抗耐药真菌活性的天然小分子化合物的研究工作 进行综述, 对它们的来源、结构、药理活性和作用机制进行分析, 以寻找其中的共性规律, 为抗耐药真菌的创新 药物研发提供理论基础。 : 协同; 抗真菌; 耐药性; 天然小分子化合物; 构效关系 : R916 : A : 0513-4870 (2014) 08-1097-08 Research progress of the natural small molecular products synergistically with antifungal agents to inhibit drug-resistant fungi TAN Shan-lun1, 2, ZHANG Da-zhi1*, JIANG Yuan-ying1* (1. School of Pharmacy, The Second Military Medical University, Shanghai 200433, China; 2. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350112, China) Abstract : The incidence of systemic fungal infections have increased dramatically, moreover, drug resistance including either primary (intrinsic) or secondary (acquired) resistance, becomes one of the main reasons accounting for the failure of treating invasive fungal infections in the past decades. Nowadays, clinically available antifungal drugs are limited and their combination in antifungal therapy was not effective. It is expected to be a new strategy to synergistically sensitize antifungal drugs against drug-resistant fungi by using new small molec