金黄膏联合桑芩合剂治疗中重度痤疮临床研究.PDFVIP

国际中医中药杂志2016年9月第38卷第9期 Int J Trad Chin Med, September 2016, Vol. 38, No.9                                   ·811 ·  ·论著 · 金黄膏联合桑芩合剂治疗 中重度痤疮临床研究 沈文彤 张慧敏 【摘要】 目的 观察金黄膏外用联合桑芩合剂治疗中重度痤疮患者的疗效。方法 将符合入选标 准的中重度痤疮患者 72 例按随机数字表法分为 2 组，每组 36 例。治疗组外用金黄膏联合内服桑芩合剂， 对照组外用夫西地酸联合内服桑芩合剂。2 组均治疗 2 个月。观察治疗前后患者粉刺、丘疹、脓疱、结节 数量及痤疮综合评分，比较患者单位面积毛囊内痤疮丙酸杆菌减少率。结果 治疗后，治疗组丘疹数量 [(28.69 ±10.50)个比(36.61 ±10.10)个，t ＝3.262]低于对照组(P ＝0.002)；脓疱数[1 (0,3)个比 3 (0,15)个， Z ＝-6.238]、结节数[0 (0,1)个比 0 (0,4)个，Z ＝-3.353]、GAGS 评分[13 (6,24)分比 20 (17,32)分，Z ＝ -6.482]低于对照组(P 值均＜0.01)；治疗组单位面积的毛囊内痤疮丙酸杆菌减少率[43.07% (-57.14%,86.23%) 比 12.68% (-34.52%,51.11%)，Z ＝-2.705]高于对照组(P ＜0.01)。结论 金黄膏外用联合桑芩合剂口服可 减轻中重度痤疮患者皮损程度，减少丘疹、脓疱、结节数量，对痤疮丙酸杆菌有抑菌作用。 【关键词】 寻常痤疮；投药，局部；梭链孢酸；外用药(中药)；痤疮丙酸杆菌；金黄膏；桑芩合剂 Topical Jinhuang unction combined with oral Sangqin mixture for the patients with moderate to severe acnevulgaris Shen Wentong, Zhang Huimin. Department of Skin, Shanghai Shuguang Hospital, Shanghai 200021, China Corresponding author: Zhang Huimin, Email: happy2003_1@ 【Abstract 】 Objective To evaluate the efficacy of topical Jinhuang unction combined with oral Sangqin mixture forthe patients with moderate to severe acnevulgaris. Methods A total of 72 patients with moderate to severe acne (Pills bury grade 2 or grade 3) were included and divided into a study group and a control group by random number table method, 36 in each group. The patients were treated for 2 months in the study group with topical Jinhuang unction combined with oral Sangqin mixture, and in the control group with topical fusidic acid combined with oral Sangqin mixture. The number of lesions and the Global Acne GradingSystem (GAGS) score for each patient were obtained and evaluated. The number offollicular Propion