阿普可乐定防止nd∶yag激光虹膜切除术后眼压升高.docVIP

???? 阿普可乐定防止Nd∶YAG激光虹膜切除?术后眼压升高 ???? ????　【摘要】　目的　了解阿普可乐定是否有效降低棕色虹膜人种激光虹膜切除术后眼压急性升高。方法　48只原发性闭角型青光眼，按年龄、性别进行匹配，分为治疗组和对照组。治疗组术前1小时和术后即刻滴用1％阿普可乐定，对照组滴用安慰剂。术后0.5、1.0、1.5、2.0、3.5小时观察眼压和其他情况。结果　激光治疗后，治疗组和对照组眼压最大升高值分别为0.62±0.67 kPa(1 kPa=7.5 mmHg)和1.13±0.87 kPa，两组间差异有显著性(P=0.03)。治疗组的眼压明显下降发生于Nd∶YAG激光虹膜切除术后0.5、1.0和1.5小时。除治疗组激光虹膜切除术后瞳孔直径明显大于对照组外，未见其他眼部和全身的副作用。结论　1％阿普可乐定在棕色人种中可以有效地防止Nd∶YAG激光虹膜切除术后眼压升高。　　【关键词】　青光眼，闭角型　　激光手术　　阿普可乐定 　Apraclonidine prevents the acute increase of intraocular pressure in brown eyes with Nd∶YAG laser iridectomy　　Zhao Jialiang, Mao Jin, Liu Xiaoli. Department of Ophthalmology, Eye Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730　　【Abstract】　Objective　To investigate if apraclonidine can effectively prevent the acute increase of intraocular pressure (IOP) in brown eyes with Nd∶YAG laser iridectomy. Methods　48 eyes with primary angle closure glaucoma were divided into treatment and control groups, which were matched by age and sex. One drop of apraclonidine was applied into the conjunctival sac at one hour before laser iridectomy and immediately after laser iridectomy in treatment group, whereas one drop of antibiotic as placebo was applied in control group at the same time. IOP, pupil diameter were measured at 0.5, 1, 1.5, 2, 3.5 hours after laser iridectomy. Results　The maximum increase of IOP after laser iridectomy was 0.62± 0.67 kPa and 1.13±0.87 kPa in treatment and control group respectively, there was a significant difference (P=0.03). The obvious decrease of IOP occurred at 0.5, 1 and 1.5 hours after laser iridectomy in treatment group. No ocular and systemic side effects were found in treatment group, except pupil diameter was obviously larger in treatment group than that in control group. Conclusion　1% apraclonidine effectively prevents the acute increase of IOP in brown eyes with Nd∶YAG laser iridectomy.　　【Key words】　Glaucoma, angle-closure　　Laser surgery　　 Apraclonidine 　　Nd∶Y