基于气道慢性炎症性疾病之肺肾气虚证型内涵的现代认识与实践.docxVIP

基于气道慢性炎症性疾病之肺肾气虚证型内涵的现代认识 与实践 基于气道慢性炎症性疾病之肺肾气虚证型内涵的现代认识 与实践 董竞成宰张红英段晓虹刘宝君孙婧吕玉宝 陈美霞罗清莉杜懿杰曹玉雪乐晶晶徐一醅 摘要：哮喘、COPD等属常见气道慢性炎症性疾病，而肺肾气虚应该是此类疾病 的基本证型，机体致炎／抑炎平衡调控机制的失衡则是此类病证的主要背景之一。 系统的临床和动物实验研究表明，伴肺肾气虚证型的哮喘及COPD，气道炎症就 更加明显，ttPA轴功能受损或紊乱就更加严重，机体致炎／抑炎平衡调控机制的 失衡关系就更加复杂。中医补肾益气方药干预疗效确切，补肾益气中药(淫羊藿、 黄芪)可调节Thl／Th2与Thl7／Treg失衡，纠正HPA轴和免疫功能紊乱，从而使 哮喘和COPD得到控制和改善，其中补肾药淫羊藿等侧重于调节HPA轴，益气药 黄芪等侧重于调节免疫，而补肾益气方药则具有重塑机体致炎／抑炎平衡调控机 制平衡的作用，且相关疗效的显现可能具有延迟性。物质基础研究显示，补肾益 气方药干预哮喘等气道慢性炎症性疾病，其发挥药效的主要成分主要来自补肾药 淫羊藿和益气药黄芪。 关键词：哮喘COPD气道慢性炎症性疾病肺肾气虚致炎／抑炎平衡调控机制 The Modern Understanding and Practice of Connotation Based on Lung and Kidney Deficiency Syndrome Type of Chronic Airway Inflammatory Di seases Jingcheng Dong*Hongying Zhang Xiaohong Duan Baojun Liu Jing Sun Yubao Lv Meixia Cheng Qingli Luo Yijie Du Yuxue Cao Jingjing Le Yizhe Xu Abstract： Asthma and COPD belong to common chronic inflammatory disease， while lung and kidney qi—deficiency i S the basic syndrome of this kind of disease，which iS caused by the disequilibrium of regulation mechanism 2l of of body’S inflammatory／anti—inflammation balance．Systematic clinical and animal studies have shown that those who have asthma and COPD together with lung and kidney qi——deficiency syndrome type are more likely to get obvious airway inflammation，severe damage and disorder of HPA axis function， complicated disequilibrium relationships of regulation mechanism of body’S inflammatory／anti—inflammation balance．TCM formula of supplementing kidney and invigorating qi have curative effect in which epimedium and astragalus membranaceus could adjust the imbalance of Thl／Th2 and Thl7／Treg，correct HPA axis and immune dysfunction SO as to improve and control asthma and COPD．Among these two medicines，epimedium which supplements kidney focuses on adjust HPA axis while astragalus membranaceus which invigorates qi focuses on adjust immune system，whose related curative effect could have the re