《星点设计—效应面法优化醋酸地塞米松果胶微丸处方》-毕业设计（论文）.docVIP

山西医科大学药学院本科毕业论文 PAGE 12 - 星点设计—效应面法优化醋酸地塞米松果胶微丸处方 [摘要]目的：优化醋酸地塞米松果胶凝胶微丸处方工艺。方法：以醋酸地塞米松为模型药物，果胶为载体材料，醋酸锌溶液为胶凝剂，采用滴制法制备醋酸地塞米松果胶结肠释药凝胶微丸；用紫外分光光度法测定微丸的载药量；用转篮法和透析袋法考察微丸在模拟胃肠液介质中的药物累积释放度，并对其释放情况进行数字化模拟；用desire expert软件对处方优化。结果：多元线性模型是描述指标与因素之间定量关系的最好模型。按照最优处方制备的微丸其载药量、释放度真实值与理论值偏差最小，模型具有良好的预测性。结论：采用星点设计-效应面法优化醋酸地塞米松果胶微丸的制备工艺处方能实现多指标的同时优化，所建立的模型具有较好的预测能力和实用性，可以很好地应用于处方筛选。 [关键词] 醋酸地塞米松；星点设计-效应面优化法 ；结肠释药；微丸 Central composite design—Dexamethasone acetate colonic delivery formulation optimization [Abstract]Objective: to optimize Formulation and process?of?dexamethasone?pectingel?pellets. Methods: to acetic acid dexamethasone for model drugs, pectin for carrier material, Zinc acetate for gelling agent,prepared acetic acid dexamethasone colon drug delivering pellets by dropping; to determinate pelletsl drug loading by UV Spectrophotometric;to investigate cumulated release rate in simulated gastrointestinal fluid media by rotating basket and dialysis bag method. Formulation optimization of desire expert software. Results: The?multivariate linear model?is?the best?model?to?describe?the quantitative relationship?between?the?indicators?and factors. Preparation of pellets in accordance with the optimal prescription drug loading, the release of the degree of real value and the minimum theoretical value of deviation, the model has good predictability. Conclusion: optimization of the prescription of dexamethasone acetate pectin pellets by Central composite design - response surface methodology can achieve multiple indicators optimization The model has good predictive ability and can be well applied to prescription screening. [key words ]Dexamethasone acetate；Central composite design-Response surface methodology；Colonic drug delivery；Pellets 星点设计—效应面法优化醋酸地塞米松果胶微丸处方 1.引 言 口服结肠定位释药系统（oral colon-specific drug delivery system,OCDDS）可以保护药物在胃、十二指肠、小肠中不释放，达到结肠部位后迅速释药，发挥局部或经吸收后发挥全身治疗的作用，从而最大限度的提高药物的疗效，减小毒副反应的发生。近年来，菌群触发型结肠定位释药系统由于具有良好的结肠释药特异性而颇受国外研究者的关注。 果胶无毒、生物可降解、来源广泛、成本低在医药领域的应用日益广泛，特