中国医科大学病理学英文课件6演示教学.pptVIP

Chapter 4. Inflammation;Section 1. Introduction 1. Definition: ;4) Significance;2. Causes of inflammation; 2. Exudation: In inflammatory foci, the escape of fluid, proteins (fibrin), blood cells from vascular wall into interstitial tissue, body cavities or surface of the body and mucosa 3. Proliferation Parenchymal: epithelium, hepatocyte Mesenchymal: fibroblast, EC, histocyte ;4. Clinical types;病 例 六;Section 2. Acute inflammation;;I. Changes of hemodynamics; (2) Related to the factors of: Body fluid: chemical mediator Nervous: axon reflection 3) Slowing of blood flow: increased permeability of the microvasculature outpouring of fluid into extracellular tissues concentration of RBC and increased viscosity of blood stasis of blood flow;Normal blood flow;2. Increased vascular permeability ;2) Cytoskeletal reorganization Delayed prolonged response induced by cytokines(IL-1, TNF, IFN-γ), increased permeability after a delay of 4 to 6 hours lasting for more than 24 hours involves venules as well as cap. the endothelial cells retract from one another 3) Increased transcytosis across the endothelial cytoplasm By transcytoplasmic channel VEGF, histamine, bradykinin, Increasing the number and the size of channels;4) Direct endothelial injury;5) Leukocyte-mediated endothelial injury;6) High permeability of new caps during repair, endothelial cells proliferate and form new blood vessels ① New vessels sprouts remain leaky until ECs differentiate and form intercellular junctions. ② Certain factors that cause angiogenesis (VEGF) increase permeability ③ Increased density of receptor for vasoactive mediators in the surface of EC;;II. Fluid exudation;;;2) Distinguish between exudate and transudate;3) Functions of exudate:;III. Leukocyte extravasation  and phagocytosis; (1) Ma