神经阻滞相关的局麻药毒性救治—LE救治LAST指南的变迁和相关科研思路探讨.pptVIP

神经阻滞相关的局麻药毒性救治—LE救治LAST指南的变迁与相关科研思路探讨;;国际专家评价;Weinberg GL, VadeBoncouer T, Ramaraju GA, et al. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998; 88: 1071-5;Weinberg G, Ripper R, Feinstein DL, et al. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med,2003; 28(3): 198-202;Weinberg GL, Ripper R, Murphy P, et al. Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med. 2006, 31(4):296-303;Weinberg GL, Di Gregorio G, Ripper R, et al. Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology. 2008;108(5):907-13;Mayr VD, Mitterschiffthaler L, Neurauter A, et al. A Comparison of the Combination of Epinephrine and Vasopressin with Lipid Emulsion in a Porcine Model of Asphyxial Cardiac Arrest After Intravenous Injection of Bupivacaine. Anesth Analg 2008; 106:1566-1571;家兔缺氧导致心跳停止模型，LE复苏无效;Hicks SD,?Salcido DD,?Logue ES,?et al.Lipid emulsion combined with epinephrine and vasopressin does not improve survival in a swine model of bupivacaine-induced cardiac arrest. Anesthesiology.?2009 Jul;111(1):138-46;Hiller DB, Gregorio GD, Ripper R. Epinephrine Impairs Lipid Resuscitation from Bupivacaine Overdose. Anesthesiology 2009; 111:498–505;Harvey M, Cave G, Prince G, et al. Epinephrine Injection in Lipid-Based Resuscitation from Bupivacaine-Induced Cardiac Arrest Transient Circulatory Return in Rabbits. Anesth Analg 2010 Jun 14.;Candela D, Louart G, Bousquet PJ,?et al. Reversal of bupivacaine-induced cardiac electrophysiologic changes by two lipid emulsions in anesthetized and mechanically ventilated piglets. Anesth Analg. 2010 May;110(5):1473-9.;Cave G, Harvey M, Prince G, et al. Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid. Anaesthesia