土茯苓复方制剂对氧嗪酸钾致高尿酸血症改善作用研究.PDFVIP

现代食品科技 Modern Food Science and Technology 2013, Vol.29, No.11 土茯苓复方制剂对氧嗪酸钾致高尿酸血症 改善作用的研究 陈露滢，杨继国，邱晓斌，谭凯元，韦庆益，袁尔东，宁正祥 （华南理工大学轻工与食品学院，广东广州 510640） 摘要：采用氧嗪酸钾灌胃建立高尿酸血症大鼠模型，并考察一种土茯苓复方制剂的降尿酸效果。结果显示，大鼠按照1.5 g/(kg·d) 剂量连续灌胃氧嗪酸钾30 d 可以建立高尿酸血症大鼠模型，在第15 d和第30 d 检测时，模型动物的血清尿酸水平与正常对照组比较 均有显著性差异，并且血清尿素氮和肌酐未见病理性改变；采用土茯苓复方制剂样品连续灌胃30 d （在第15 d 和第30 d 检测），样品 大、小剂量均可以显著降低模型动物的血清尿酸、尿素氮含量；而样品大剂量可以显著降低模型动物的血清肌酐水平。采用该土茯苓 复方制剂样品连续灌胃后均可以不同程度地降低相应模型动物的血清尿酸、尿素氮和肌酐的含量。因此，该土茯苓复方制剂对氧嗪酸 钾致高尿酸血症有一定的改善作用。 关键词：土茯苓复方制剂；高尿酸血症；氧嗪酸钾 文章篇号：1673-9078(2013)11-2649-2652 Effect of Smilax Glabra Formulated Preparation on the Hyperuricemia Induced by Potassium Oxonate CHEN Lu-ying, YANG Ji-guo, QIU Xiao-bin, TAN Kai-yuan, WEI Qing-yi, YUAN Er-dong, NING Zheng-xiang (College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640 , China) Abstract: The rat model of hyperuricemia was established by oral gavage with potassium oxonate, and the effect of a Smilax Glabra prescription on the hyperuricemia was studied. The rat model of hyperuricemia was established in accordance with 1.5 g/(kg·d) continuous intragastric dose by potassium oxonate for 30 d. When tested at the 15th and 30th d, serum uric acids in the model were significantly different to the normal control group, urea nitrogen and creatinine in the serum had no pathological change. After continuously oral gavage for 30 d with th th Smilax Glabra p rescription ( 15 and 30 d tests), the serum uric acid and urea nitrogen were reduced in the corresponding model with different doses and the creatinine was significantly reduced with high doses. Therefore the Smilax Glabra p rescription has a certain effect on potassium oxonate-induced hyperuricemia. Key words: Smilax G