prosolve超强崩解填充剂JRS.ppt

* * * * * * * * * * * * * * * * * * * * * 提高 * 提高 * 提高 * * * * * * * * * * * * * * * PRUV 优势是什么? 提高和促进: 配方稳定性 生产收益率 溶出率 更容易 开发新配方 生产规模化 PRUV? 优势? 与硬脂酸镁比较… 混合 持久 片剂的崩解时间 乐观 片剂的润滑效果 相当 片剂的润滑性能 优越 片表面 提高 更快 API 溶解 API 稳定性 改善 What is PRUV? a particle size distribution of of 10 μm. 基本功能 超润滑 PRUV 的功能? 次要功能 抗粘 (解决粘冲问题) 减少颗粒间的摩擦力 (在压片时) 改善流动性 (from the hopper, through the feed frame and into the die) 0 20 40 60 80 100 120 140 0 1000 2000 3000 4000 Compression Force (lb.) Ejection Force (lb.) 1% PRUV 1% Mg stearate Lubricant Effect on Ejection of DC Lactose Tablets Conclusion: PRUV’s lubricating properties are comparable to those of Mg stearate. 为什么选择 PRUV?:相当的润滑效果 Blends with PRUV showed equivalent ejection forces. 为什么选择 PRUV?:相当的润滑效果 避免 与Magnesium Stearate 不相容 Aspirin Iron salts Some vitamins Alkaloidal salts Compounds sensitive to magnesium Strong organic acid salt formers 为什么选择PRUV?:增强稳定性 Tablet hardness is less sensitive to lubricant level with PRUV. 为什么选用PRUV?:减小配方的敏感度与乳糖混合直压 PRUV showed little variation in tablet hardness at varying levels and blend times. Why choose PRUV?:Enhanced Formulation Robustness Magnesium Stearate shows significant variation in tablet hardness at varying levels and blend times. Why choose PRUV?:Enhanced Formulation Robustness Magnesium stearate showed tablet disintegration variation at varying levels and blend times. Why choose PRUV?:Enhanced Disintegration Profile PRUV showed little variation in tablet disintegration regardless of blend times and lubricant levels. Why choose PRUV?:Enhanced Disintegration Profile PRUV 0 20 40 60 80 100 0 10 20 30 40 50 60 Time (Min.) % Dissolved 2M Pruv 20M Pruv 2M MgSt 20M MgSt Unique dissolution profiles are possible. Why choose PRUV?:Superior Dissolution Dissolution of Felodipin 何时选用PRUV? Magnesium stearate 相关问题 减缓片剂的崩解 减缓溶出率 优化配方,生产规模化 使用PRUV的配方对过润滑不敏感. 硬度增加,降低脆碎度 泡腾片 通常使用量 0.2% to 2% Low levels 0.1-0.3% with PROSOLV? What is the PRUV Advantage? 优越在: 配方的稳定性 生产产量 溶出率