namenda(memantinehcl)处方使用指导.pdfVIP

NAMENDA - memantine hydrochloride tablet NAMENDA - memantine hydrochloride s olution NAMENDA - memantine hydrochloride Fores t Laboratories , Inc. HI GHLI GHT OF PRE CRIBING INFORMAT I ON T he se hig hlig hts do no t inc lu de all the inf o rm atio n ne e de d to use NAMENDA safe ly and effe ctive ly. e e full pre sc ribing inf o rm atio n f o r NAMENDA. NAMENDA (m e m antine HCl) tablets, f o r o ral use NAMENDA (m e m antine HCl) s o lutio n, f o r o ral use Initial U. . Approval : 20 0 3 INDI CAT I ON AND U AGE NAMENDA is an N-m ethyl-D-aspartate (NMDA) re ceptor antagonist indicate d for the tre atm ent of m oderate to severe dem entia of the Alzheim ers type . ( 1) DO AGE AND ADMINI T RAT I ON May e taken with or without food (2) Initial dose is 5 m g once daily . Incre ase dose in 5 m g increm ents to a m aintenance dose of 10 m g twice daily . A minimum of 1 we ek of tre atm ent with the previous dose should e o serve d e fore incre asing the dose . (2) Severe renal impairm ent : re comm ende d dose is 5 m g twice daily . (2) DO AGE FORM AND T RENGT H T a lets : 5 m g and 10 m g (3) Oral Solution : 2 m g/mL (3) CONT RAINDI CAT I ON NAMENDA is contraindicate d in patients with known hypersensitivity to m em antine hydrochloride or to any excipients use d in the formulation . (4) WARNING AND PRECAUT I ON Conditions that raise urine pH m ay de cre ase the urinary elimination of m em antine , re sulting in incre ase d plasm a levels of m em antine . (5.1, 7.1) ADVER E REACT I ON Most comm on adverse re actions (≥ 5 % and gre a