《痢疾dysentery》-精选课件(公开).pptVIP

Bacillary Dysentery (shigellosis) Dept. Of Infectious Disease Wang Jingyan Definition Acute infectious disease of intestine caused by dysentery bacilli Place of lesion: sigmoid rectum Pathological feature: diffuse fibrious exudative inflammation Clinical manifestation: fever, abdominal pain, diarrhea, tenesmus , stool mixed with blood, mucus pus. Even companied with marked toxicity and shock,toxic-encepholopthy. Etiology Causative organism: dysentery bacilli, genus shigella, gram-stain negative, short rod,non-motile Groups: 4 groups 50 serotypes - S. Dysenteriae-the most sever - S. Flexnerii-the epidemic group and easily turn to chronic - S. Boydii-tropical and subon - S. sonnei-the most mild Etiology Pathogenicity: - virulence (endotoxin) - interotoxin (exotoxin) - invasiveness (attach-penetrate-multiply) Resistance: Strong.1-2week in fruits,vegetable and dirty soil. heat for 60℃ 30 min Epidemiology Source of infection: - patients - carriers Route of transmission: fecal-oral route Suceptibility of population:immunity after infection is short and unstead,no cross-immune Epidemic features: - season: summer fall - Flexneri, Soneii, dysentery - age: younger children Pathogenesis Number of bacteria toxicity immunity invasiveness - attachment - penetration - multiplication Pathology Site of lesion: entire large bowel-colone, sigmoid rectum Feature: acute: diffuse fibrinous exudative inflammation, hyperemia, edema, leukocyte infiltration, superficial necrosis chronic: edema, polypoid hyperplasis toxic: endothelial cell of micro-capillary necrosis Clinical manifestation Incubation period: 1-2 day, (Hrs. To 7 days) Acute dysentery common type: onset in sudden, shiver, high fever abdominal pain diarrhea:stool mixed