高通量测序技术在微生物基因组学中的应用.pptVIP

高通量测序技术在微生物研究中的应用 崔玉军 2010.07 分类学 转录组学 进化生物学 挖掘基因资源 宏基因组学 分类学 The concept of species: 18th century Whole genome sequencing Stablizing species’ status How should we define a species in genomics era? To find novel way to define the concept of species by using genome information! Nature review microbiology, Dirk Gevers et al. 2005 Strong correlation between 16S rRNA gene identity and AAI (R2=0.84; P＜ 0.0001) 分类学 转录组学 进化生物学 挖掘基因资源 宏基因组学 Construct the robust phylogeny with high resolution Keim P et al. 2004. Infect, Genet Evol. 205 Science, 2010 46 sSNPs PNAS, Mark et al, 2004 2298 SNPs Identifica