光与组织的相互作用.pptVIP

光与组织的相互作用 组织光学 光的吸收、散射和透射 生物组织的光学特性 激光的生物学效应 Outline What is Tissue Optics Absorption in Tissue Absorption Process and Parameters Typical absorbers in Tissue What is Tissue Optics? Definitions from dictionary Optics: a science that deals with genesis and propagation of light changes that it undergoes and produces Tissue: an aggregate of cells which usually of a particular kind together with their intercellular substance that form one of the structural materials of a plant or an animal then,What is Tissue Optics?Tissue optics is combination of tissue and optics. Tissue is my subject of interest and optics is my investigating principle. Tissue Optics Optical Signal from Tissue Large number of Biological Molecules Functional and Structural information Noninvasive Near real time Optical signal from tissue can gain functional and structural information of large number of biological molecules with noninvasive and real time. Objectives of Tissue Optics Key Question: How many photons per second will reach the tissue chromophore and be absorbed? Absorption is important because it transfers energy to tissue 1. To find the light energy per unit area per unit time that reaches a target chromophore at some position 2. To develop methods by the absorption and scattering properties of tissue can be measured Ultimate Goal of Tissue Optics will be that Assess all optical properties noninvasive in living tissue (in vivo) We must face Difficulties that Tissue is a complicated heterogeneous system and Requires noninvasive in vivo information for meaningful diagnostic and therapeutic purposes Absorption Extraction of energy from light by a molecular species Applications of absorption in tissue as follows Diagnostic applications: Transitions between two energy levels of a molecule that are well defined at specific wavelengths could serve as spectral fingerprint of the molecule Various types of Chromophores (light absorbers) in Tissue Wavelength-dependen