肿瘤干细胞的认知历程与研发热点.PDF

第21卷 第4期 生命科学 Vol. 21, No. 4 2009年8月 Chinese Bulletin of Life Sciences Aug., 2009 文章编号 ：1004-0374(2009)04-0549-07 肿瘤干细胞的认知历程与研发热点 * 罗海涛 ，许瑞安 (华侨大学分子药物研究所 分子药物教育部工程研究中心，泉州 362021) 摘　要：肿瘤组织中存在一小群能够自我更新、增殖和分化，对肿瘤的发生、发展、复发、转移 起决定作用的细胞，即肿瘤干细胞(cancer stem cells, CSCs)。在传统理论方法已不能攻克癌症的情况 下，肿瘤干细胞理论为我们重新认识肿瘤的起源和本质提供了新的方向和视角。从20 世纪50 年代至今， 随着生物技术的发展，肿瘤干细胞理论经历了从设想到验证的漫长历程。但该理论自提出之日起便受到 来自各方面不同观点的质疑。当今针对肿瘤干细胞癌症治疗主要集中在靶向问题上。因此，寻找特异 的肿瘤干细胞标志物，探索肿瘤干细胞与周围微环境间的复杂关系以及发现调控其功能的关键信号通路 成为当前研究的热点。 关键词：肿瘤干细胞; 认知历程; 靶向策略; 质疑 中图分类号：R730.21; Q813　　文献标识码：A 　 Progress in cancer stem cell research LUO Hai-tao*, XU Rui-an (Institute of Molecular Medicine Huaqiao University Molecular Medicine Engineering Research Center, Ministry of Education, Quanzhou 362021, China) Abstract: Tumours consisit of a minority subpopulation of tumor cells (cancer stem cells, CSCs) with stemness properties such as self-renewal, proliferation and differentiation, which is responsible for tumor occurrence, growth and metastasis. In the context of failure in conventional anti-tumor treatments, the theroy about cancer stem cell provides a new insight to recognise origin and essence of tumours. From 1950s to the present, this theroy has experienced from idea to validation with development in biotechnology. However, since the propo- sition of cancer stem cell theory, the opposite opinion has exited. Current researches are mainly focusing on targeting strategies, such as in search of spec