05蛋白质作用力与折叠2017.pptVIP

The 26S proteasome is highly conserved in all eukaryotes. The two subassemblies are the 20S core particle and the 19S regulatory particle. (a) (PDB ID 1IRU) The core particle consists of four rings arranged to form a barrel-like structure. Each of the inner rings has seven different β subunits (light blue), three of which have protease activities (dark blue). The outer rings each have seven different α subunits (gray). (b) A regulatory particle forms a cap on each end of the core particle. The core particle is colored as in (a). The base and lid segments of each regulatory particle are present