物理系-普通生物学-20199-Cell Communication.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * TGF-b-Smad Signaling Pathway (1) Note: Both type I and type II are dimers * TGF-b-Smad Signaling Pathway (2) For feedback regulation: Some target genes encode inhibitory smads (Smad6, 7), which act as decoys to prevent functional Smads from binding to receptors * Six Classes of Enzyme-Linked Receptors Receptor tyrosine kinase: - Phosphorylate specific tyrosines on their intracellular signal proteins Tyrosine-kinase-associated receptors: - Associate with intracellular proteins with tyrosine kinase