chiral separation methods for pharmaceutical and biotechnological products (ahujachiral separation methods) a look into the future chiral analysis using chemical sensor technology英文精品课件.pdf

CHAPTER 14 A Look into the Future: Chiral Analysis Using Chemical Sensor Technology GREGORY K. WEBSTER Global Analytical Research and Development, Abbott Laboratories, Abbott Park, Illinois WILLIAM J. BUTTNER International Center for Sensor Science and Engineering, Illinois Institute of Technology, Chicago, Illinois 1 INTRODUCTION Currently, it is conservatively estimated that nearly 40% of the drugs under development within the pharmaceutical industry are chiral [1]. Often, in the early stages of drug development, the synthetic process yields racemic mixtures that need to be separated from the production perspective and assayed from an ana- lytical perspective. Chiral screening systems based on liquid or supercritical fluid chromatography or capillary electrophoresis systems have been investigated to provide a more systematic approach to chiral method development [2,3]. Testing for enantiomeric purity is neither as straightforward nor as systematic as it is with achiral chromatography. Selection of chromatographic conditions and stationary phases for chiral applications involves a great deal of trial and error, which can be time consuming and costly. Such screens involve hours of continuous operation per sample, use several thousand dollars’ worth of chromatographic columns, and may or may not lead to a promising result. Although chiral screening for method development is an improvement in efficiency relative to the less structured trial- and-error scenarios, it still has significant time and material costs. Investment in chiral method development alternatives is justified. One leading alternative is the use of chemical sensors. Sensor technology can potentially bring about improved cost and time efficiencies in the development of chiral purity assays. Chiral Separation Methods for Pharmaceutical and Biotechnological Products, Edited by Satinder Ahuja Copyright © 2011 John Wiley Sons, Inc.