role of nigella sativa and its constituent thymoquinone on chemotherapy-induced nephrotoxicity evidences from experimental animal studies.[2017][nu英文精品课件.pdf
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nutrients
Review
Role of Nigella sativa and Its Constituent
Thymoquinone on Chemotherapy-Induced
Nephrotoxicity: Evidences from Experimental
Animal Studies
Marco Cascella 1,†, Giuseppe Palma 2,†, Antonio Barbieri 2, *,†, Sabrina Bimonte 1,†,
Nagoth Joseph Amruthraj 2,3, Maria Rosaria Muzio 4, Vitale del Vecchio 2, Domenica Rea 2,
Michela Falco 2, Antonio Luciano 2, Claudio Arra 2,‡ and Arturo Cuomo 1,‡
1 Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori—IRCCS–“Fondazione G. Pascale”,
Via Mariano Semmola, 80131 Naples, Italy; m.cascella@istitutotumori.na.it (M.C.);
s.bimonte@istitutotumori.na.it (S.B.); a.cuomo@istitutotumori.na.it (A.C.)
2 S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori—IRCCS—“Fondazione G. Pascale”,
80131 Naples, Italy; palma.giuseppe@ (G.P.); amruthjon@ (N.J.A.);
vitale_84@hotmail.it (V.d.V.); d.rea@ist iutotumori.na.it (D.R.); michelafalco_89@libero.it (M.F.);
a.luciano@istitutotumori.na.it (A.L.); c.arra@istitutotumori.na.it (C.A.)
3 Clinical, Experimental and Medical Sciences, Chair of Nephrology, Department of Cardio-Vascular Medicine,
University of Study of Campania “Luigi Vanvitelli”, 81100 Caserta, Italy
4 Division of Infantile Neuropsychiatry, UOMI-Maternal and Infant Health, Asl NA 3 SUD, Torre del Greco,
Via Marconi, 80059 Naples, Italy; maramuzio@yahoo.it
* Correspondence: a.barbieri@istitutotumori.na.it; Tel.: +39-081-590-3259
† These authors have contributed equally.
‡ These authors are co-last authors.
Received: 12 May 2017; Accepted: 15 June 2017; Published: 17 June 2017
Abstract: Background: Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore,
new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is of
note that Nigella sativa (NS), or its isolated compound Thymoquinone (TQ), has a potential role
in combating chemoth
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