reverse biosynthesis generating combinatorial pools of drug leads from enzyme-mediated fragmentation of natural products.反向生成组合生物合成的药物先导物池从酶促反应而引起天然产物细英文精品课件.pdf

Accepted Article Title: Reverse Biosynthesis: Generating Combinatorial Pools of Drug Leads From Enzyme-Mediated Fragmentation of Natural Products Authors: Tomas Richardson-Sanchez, William Tieu, and Rachel Codd This manuscript has been accepted after peer review and appears as an Accepted Article online prior to editing, proofing, and formal publication of the final Version of Record (VoR). This work is currently citable by using the Digital Object Identifier (DOI) given below. The VoR will be published online in Early View as soon as possible and may be different to this Accepted Article as a result of editing. Readers should obtain the VoR from the journal website shown below when it is published to ensure accuracy of information. The authors are responsible for the content of this Accepted Article. To be cited as: ChemBioChem 10.1002/cbic.201600636 Link to VoR: /10.1002/cbic.201600636 A Journal of ChemBioChem 10.1002/cbic.201600636 COMMUNICATION Reverse Biosynthesis: Generating Combinatorial Pools of Drug Leads From Enzyme-Mediated Fragmentation of Natural Products Tomas Richardson-Sanchez, William Tieu, and Rachel Codd* Abstract: A combinatorial pool of hydroxamic acid fragments as retain structural elements of the parent compound, such as potential metalloprotein drug leads was generated from the enzyme- chirality and unusual functional groups, as desirable for a useful mediated hydrolysis of the natural product desferrioxamine B (DFOB). drug or drug lead. Third, while the parent natural product might DFOB is a metabolite produced by Streptomyces pilosus for iron