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Typhoid fever and Bacillary Dysentery
n Types by rod-shaped bacteria
Ø Tuberculosis
Ø Typhoid fever
Ø Bacillary dysentry
Ø Leprosy
Ø Others
n Brief overview
Ø Systemic diseases: Enteric fever
Ø Salmonella typ hi
Children and adolescents in endemic areas
Ø Salmonella p aratyp hi
Travelers, developed countries
n Brief overview
ØTransmission route:
Fecal-oral, from the patients and carriers (Gallbladder
colonization →chronic carrier state)
ØMorpholgy:
Acute granulomatous inflammation, but lack of
neutrophils infiltration
n Chronic carrier state
n Etiology
Salmonella typ hi
ØGram-negative bacilli, motile
ØSomatic antigen (O antigen)
Diagnosis
ØFlagellar antigen (H antigen)
ØSurface antigen (Vi antigen) Chronic carriers
n Morphology
Systemic disease
Ø Lymphoid tissues
l Intestine: ileum
l Mesenteric lymph nodes
l Spleen
l Liver
l Bone marrow
Ø Gallbladder
n Morphology Granulomatous inflammation
Four stages
Ø A: Hyperplasia
Ø B: Necrosis
Ø C: Ulceration
Ø D: Healing
N indicates healthy intestine
N A B C D
Typhoid nodule
n Morphology
Typhoid cell :Large macrophages
containing erythrocytes, lymphocytes,
bacteria,necrotic cellular debris
Typhoid nodule:Typhoid granuloma,
aggregates of typh
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