Suzuki-Miyaura_偶联反应在医药工业上的应用.pptxVIP

Suzuki-Miyaura 偶联反应在 医药工业上的应用;Suzuki-Miyaura Coupling;二、反应机理;三、Suzuki-Miyaura Coupling在医药工业中的应用实例 1. Boronic Acid and Aryl Chloride Coupling 2. Boronic Acid and Aryl Bromide Coupling 3. Boronic Acid and Aryl Iodide Coupling 4. Boronic Acid and Alkenyl Triflate Coupling 5. Borane and Aryl Halide Coupling 6. Borane and Alkyl Halide Coupling 7. Boronic Ester and Aryl Halide Coupling 8. Boronic Ester and Alkyl Halide Coupling 9. Borate Complexes;1. Boronic Acid and Aryl Chloride Coupling ;1、Pd2(dba)3[三(二亚苄基丙酮)二钯], P(t-Bu)3, KF ，THF，无水条件，无产物 2、更换溶剂如二氧六环，碱如Cs2CO3,CsF, or K3PO4，也无产物 3、发现