M胆碱受体阻断药.pptxVIP

第八章 胆碱受体阻断药(I) M胆碱受体阻断药 ;Muscarinic receptor antagonists (－) muscarinic cholinergic receptors at neuroeffector (－) the effects of ACh （smooth muscle, cardiac muscle, gland cells, peripheral ganglia and in CNS. muscarinic receptor antagonists includes the naturally occurring alkaloids (atropine, scopolamine) semisynthetic derivatives of these alkaloids synthetic congeners;1. SOURCE AND CHEMISTRY;Atropine natural congeners;2. 体内过程 (1) Atropine（叔胺类），PO易吸收，F 50％，可经粘膜吸收，皮肤吸收差，全身分布（CNS）, 尤其是scopo