2016细胞增殖与细胞凋亡1.pdfVIP

‘Life is cell activity; its uniqueness is the uniqueness of the cell.’ Rudolf Virchow，1958 •鲁道夫菲尔绍被尊为细胞病理学之父 •第一个发现白血病 •‘每一个细胞来自另一个细胞’ •多产作家 1 （1821-1902） Pathophysiology-Chapter11 Abnormal Cell Proliferation, Apoptosis and Disease Min Li limin65@mail.sysu.edu.cn School of Pharmaceutical Sciences, SYSU 2 Outline Part I: cell proliferation and disease • Cell cycle • Cell cycle control system Part II, apoptosis and disease • Apoptosis • Apoptosis and disease 3 Proliferation (cell number) Differentiation Apoptosis (cell type) (Clear damaged cell) Cell Quality and Quantity 【Cell Proliferation】 Cell proliferation is a process of cell division and regeneration, which results in an increase in the cell number with exact passages of genetic information to their daughter cells. 4 Normal cells obey strict rules Divide only when told Rather than misbehave 5 【Cell cycle】 Cell cycle is comprised of a set of sequential phases which lasts from the end of last mitosis to the end of this mitosis. 6 Cell Cycle