铜催化含磷吲哚化合物C-3位芳基化反应的研究.pdfVIP

铜催化含磷吲哚化合物C-3 位芳基化反应的研究 中文摘要 有机磷化合物因其独特的理化性质被广泛的应用于有机合成化学、药物化学、 材料化学、农药等领域，特别是有机磷配体在有机合成化学和不对称催化反应中发 挥着重要的作用，其可以在过渡金属催化反应中提高反应的催化效率，因此发展简 单高效的方法合成此类化合物受到科学家们广泛的关注。本论文主要研究了廉价金 属铜催化含磷吲哚化合物C-3 位芳基化反应，全文主要由两个章节构成: 第一章节为文献综述，详细的论述了近年来过渡金属催化吲哚C-H 官能团化反 应的研究进展，主要从吲哚C-2 和C-3 位芳基化，炔基化，烷基化，酰基化等官能 团化分别介绍。 第二章节是硕士期间开展的研究工作，研究了铜催化含磷吲哚化合物与高价的 苯基三氟甲烷磺酸碘鎓盐发生吲哚C-3 芳基化的反应，简单高效地合成了一系列3- 芳基吲哚膦氧化合物，该策略条件温和，操作简单，对新型膦配体的合成策略和 设计具有一定的影响。 关键词：过渡金属催化，有机磷化学，芳基化，吲哚化合物 I Study on Copper-Catalyzed C-3 Arylation of Phosphorus-containing Indole Abstract Organophosphorus compounds have widespread applications in organic synthetic chemistry, medicinal chemistry, materials science, pesticides and other fields due to their unique physical and chemical properties. In particular, organophosphorus ligands play an important role in organic synthetic chemistry and asymmetric catalytic reactions. They can be effective in promoting metel-catalysed reactions, so the development of simple and efficient methods to synthesize such compounds has attracted wide attention from scientists. This paper mainly studies the arylation of C-3 position of phosphorus-containing indole compounds catalyzed by cheap metal copper. The full thesis is mainly composed of two chapters: The first chapter is a literature review. It includes the recent research progress of transition metal-catalyzed indole C-H functionalization, which was summarized from the five aspects to introduce: the indole C-2 and C-3 arylation, alkynylation, and alkylation, acylation and other functional groups. The second chapter is the research carried out during my masters