手性三级醇的合成.pdfVIP

Synthesis of Chiral Tertiary Alcohols 2010/05/29 B4 1. Addition of alkyl group to ketones O HO R R R R R R: 2. Migration of alkyl group from alkyl borate R1 R4 R1 HO R5 R B C R5 R2 B C R4 R R 2 R3 Y R3 R5 1 4 1. Addition of alkyl group to ketones Nu L* R O+ R L* : chiral legand Nu NMe OH O OH + ZnPh2 (-)-DAIB Ph R R 15 mol%, rt, tol R R MeOH (1.5 eq) 60-91% ee Fu, G. C*. et al J. Am. Chem. Soc. 1998, 120, 445 Me2 Me2 O NMe2 N N ZnR2 Zn R ZnR2 Zn R R R OH O O