2017.10.23科室讲课 何国栋.pptxVIP

Remote Limb Ischaemic Postconditioning ProtectsAgainst Myocardial Ischaemia/ Reperfusion Injuryin Mice: Activation of JAK/STAT3-Mediated Nrf2 Antioxidant Signalling ;Backgroud;Nrf2（nuclear?factor? erythroid?2-related?factor): Nrf2 is a master redox regulator of the antioxidant defence system, including HO-1, quinone oxidoreductase-1 (NQO1), and SOD. Nrf2-antioxidant signalling plays a significant role in protecting cells against oxidative stress . Under the basal condition, Nrf2 is retained in the cytoplasm by Keap1-CUL3 ubiquitin E3 ligase complex,which functions as an inhibitor