肿瘤学研究进展 Oncology-TJ.pptVIP

Yao et al, Trends in Cancer (in press) Non-coding driver genetic alterations Activation of oncogenes(2) 2. Copy number alterations: Abnormal DNA replication of a DNA segment including amplification (ERBB2) that results in gain-of function Beroukhim R et al Nature 2010 Top 20 genes with gain of copy number in 26 cancer types Amplification of Myc drives many oncogenic pathways Active gene Myc Promoter Myc Myc Myc Myc Cancer cell Active gene Promoter Myc Normal cell 3. Chromosomal translocations: fuses two genes together to produce a hybrid gene encoding a chimeric protein, whose activity, un