肿瘤学研究进展 肿瘤分子靶向治疗－－研究生授课1025.pptVIP

Mutant – 7.4 vs 7.3 weeks Wild type – 12.3 vs. 7.3 weeks P= 0.0001 爱必妥在肠癌中的疗效预测biomarker Oncotype DX 21 Gene Recurrence Score (RS) Assay PROLIFERATION Ki-67 STK15 Survivin Cyclin B1 MYBL2 ESTROGEN ER PR Bcl2 SCUBE2 INVASION Stromolysin 3 Cathepsin L2 HER2 GRB7 HER2 BAG1 GSTM1 REFERENCE Beta-actin GAPDH RPLPO GUS TFRC CD68 16 Cancer and 5 Reference Genes From 3 Studies Category RS (0 – 100) Low risk RS 18 Int risk RS ≥ 18 and 31 High risk RS ≥ 31 Recurrence Score and Distant Recurrence-Free Survival 40 35 30 25 20 15 10 5 0 0 5 10 15 20 25 30 35 40 45 50 Recurrence Score Rate of Distant R