分子药理学ppt课件.pptx

分子药理学;教学大纲;课程内容;分子药理学（Molecular Pharmacology);药物的作用机制;Receptor;DRUG RECEPTORS AND BIOLOGICALRESPONSES;Agonist vs Antagonist;SECOND-MESSENGER SYSTEMS;The specific binding sites for agonists occur at the extracellular surface, while the interaction with G proteins occurs with the intracellular portions of the receptor. The general term for any chain of events initiated by receptor activation is signal transduction.;11;THE CHEMISTRY OF DRUG–RECEPTORBINDING;DYNAMICS OF DRUG–RECEPTORBINDING;DOSE–RESPONSE RELATIONSHIP;Quantal Relationships;Therapeutic Index;Protective Index;Potency and Intrinsic Activity;DRUG ANTAGONISM;Equilibrium vs non- equilibiurm;Noncompetitive Antagonism