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抗精神失常药的概念和分类;Why ?;神经兮兮
;Neuropathy;Introduction;2、classification;1)the most familiar,
2)inpatient 60~70%;
3)thought and behavior
----cloven(分裂)
4) limbic system (边缘系统)
DA function??.;Mania-depressive disorder
;3、anxiety;10月10日是世界精神卫生日;Classification of drugs;§1 Antipsychotic Drugs; chlorpromazine, CPZ 氯丙嗪 (wintermin 冬眠灵);chlorpromazine; mechanism; Clinical uses; 2、Antiemetic effects (镇吐作用); ; 3、influence of temperature regulation;Clinical uses; 配合物理降温?使体温降至34℃以下? 机体进入“冬眠”状态。BMR?,对各种病理刺激的反应性?,组织对缺氧的耐受力 ? 。;4、? the effects of CNS depressants; II. autonomic nerve system ; III. endocrine system; [adverse reactions]; 2. extrapyramidal system reactions 锥体外系反应;3.allergic reactions
4.acute toxication
po. large dose: 1~2 g / time,
clinical symptoms:
narcoma ,Bp?? shock,
(麻醉性昏睡)
cardiac damage, arrhythmia……
[contraindications] p.160;brief summary; other antipsychotic drugs p.161-163;§2 Antimanic drugs;4. mechanism is complex; p.164
5. mania and the manic state of schizophrenia
clinical first choice;
6. adverse reaction
?safe margin is narrow;
?common adverse reaction
? acute toxication: CNS(–) coma…, death .
withdrawal, treatment: iv. 0.9% NaCl;§3 Antidepressant drugs;3. mechanism: inhibit the reuptake of NA、5-HT in the brain.
4. Clinical uses:
different types of depression, enuresis(遗尿症), anxiety and phobia(恐怖症).
5. Adverse reactions: M-R (–), CNS symptom…
[ drug interaction ] p.165;Other drugs p.166-170;1.Describe the actions and uses of CPZ.
2. Please explain the effects and adverse reactions of CPZ by receptor theory.
3. List the name used for mania or depressive.;good bye;THANK YOU
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