药理学英文试题含复习资料.docxVIP

1山东大学医学院 ( 2005 —— 2006 学年第 二学期) 级 医学七年制 药理学期末考试试题 ( A 卷) 二、选择题： ( A 型每题 0.5 分， X 型每 题 1分 , 共 50 分) Type A choice questions (only one answer is correct) Which of the following is classified as belong to the G protein coupling receptors? GABAA receptor badrenergic receptor insulin receptor nicotinic II receptor hydrocortisone receptor Which of the following is unlikely to be associated with oral drug administration of an entericcoated dosage form? irritation to the gastric mucosa with nausea and vomiting destruction of the drug by gastric acid or digestive enzymes unpleasant taste of the drug formation of nonabsorbable drugfood complexes variability in absorption caused by fluctuations in gastric emptying time Which of the following compounds will be absorbed to the least extent in the stomach? ampicillin (pKa=2.5) aspirin (pKa=3.0) warfarin (pKa=5.0) Phenobarbital (pKa=7.4) propranolol (pKa=9.4) Which of the following terms is most likely to be associated w ith “ a rapid reduction in the effect of a given dose of a drug after only one or two doses ”? supersensitivity tachyphylaxis tolerance hyposensitivity anaphylaxis A weak acidic drug with 4.4 of pKa, if the stomach juice pH is 1.4, plasma pH is 7.4, when the distribution balance is reached, the drug concentration ratio between plasma and stomach juice is 100 0.001 1000 10000 0.01 In this graph ， drugs A ， B and C are analogs ，then A has a greater potency than B A has a greater efficacy than C B has less potency than C A has a greater potency than C B has a greater efficacy than C Aspirin is a weak acid with 3.5 of pKa, what percentage of lipidsoluble form will be in the stomach juice with 2.5 of pH? 0.99% 9% 9.09% 90.9% 99.9% The contractile effect of various doses of norepinephrine (NE) ( X) alone on vascular smooth muscle is represented in the figure below. When combined with an antagonist ( IC or INC), a shift in the doseresponse curve occurs. The curve labeled X+INC would mostly likely occur when vascular smo