中医传统功法联合培土化毒方在SOX方案治疗晚期结直肠癌中的临床疗效.docxVIP

中医传统功法联合培土化毒方在SOX方案治疗晚期结直肠癌中的临床疗效 打开文本图片集 ） 摘要：目的 觀察中医传统功法联合培土化毒方及SOX方案治疗结直肠癌的疗效及安全性。方法 将20XX年1月～12月在辽宁中医药大学附属三院就诊诊断为晚期结直肠癌的患者80例，随机分为对照组与治疗组，每组40例。对照组予SOX方案，治疗组在此基础上采用中药处方联合中医传统功法治疗。比较两组肿瘤病灶进行评价、中医症状评分、体力状况评分、观察近期疗效及安全性指标。结果 治疗组有效率为35.00%，临床获益率82.50%，分别高于对照组的32.50%、80.00%，差异无统计学意义（P0.05）。治疗组总有效率为65.00%，高于对照组的42.50%，治疗组治疗前后中医症状积分比较，统计学意义均显著（P0.01）;对照组治疗前后比较，差异无统计学意义（P0.05）;治疗后治疗组中医症状积分低于对照组，统计学意义显著（P0.01）;治疗后治疗组KPS评分高于对照组，统计学意义显著（P0.01）;两组治疗期间无死亡病例，主要的不良反应为骨髓抑制、消化道反应以及末梢神经炎等。两组白细胞减少分度比较，统计学意义显著（P0.01）;在恶心呕吐分度比较，差异有统计学意义（P0.05）;治疗组其它毒性反应发生率均较对照组低，但差异均无统计学意义（P0.05）。结论 中医传统功法联合培土化毒方及SOX方案治疗结直肠癌能改善患者症状，减轻化疗不良反应，提高生活质量。 关键词：传统功法;培土化毒方;SOX方案;结直肠癌 Abstract：Objective To observe the efficacy and safety of traditional Chinese medicine combined with Peifang Huadu Decoction and SOX regimen in the treatment of colorectal cancer.Methods 80 patients with advanced colorectal cancer who were diagnosed in the Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January to December 20XX were randomly divided into control group and treatment group， with 40 cases in each group. The control group was given the SOX regimen， and the treatment group was treated with traditional Chinese medicine prescription combined with traditional Chinese medicine. The tumor lesions of the two groups were compared， TCM symptom scores， physical status scores， and short-term efficacy and safety indicators were observed.Results The effective rate of the treatment group was 35.00%， and the clinical benefit rate was 82.50%， which was higher than 32.50% and 80.00% of the control group， respectively，the difference was not statistically significant （P0.05）. The total effective rate of the treatment group was 65.00%， which was higher than that of the control group 42.50%. The scores of TCM symptom scores before and after treatment in the treatment group were statistically significant （P0.01）.There was no significant difference between the control group and the