首发未服药精神分裂症患者血浆IL-6水平与抑郁症状的相关性.docxVIP

首发未服药精神分裂症患者血浆IL-6水平与抑郁症状的相关性 杨金玲　林霜　曹阳　李亚平　刘兰英 [摘要] 目的 探讨首发未服药精神分裂症患者血浆促炎细胞因子IL-2、IL-6、IL-8、TNF-α与抑郁症状的关系。方法 选择浙江省立同德医院（浙江省精神卫生中心）20XX年10月～20XX年12月诊治的首发未服药精神分裂症患者100例为精神分裂症组;选择同期该地区社会招募的健康人群80例为对照组。采用阳性和阴性症状量表（Positive and negative syndrome scale，PANSS）评估患者的精神症状，采用卡尔加里精神分裂症抑郁量表（Calgary depression scale for schizophrenia，CDSS）评估患者抑郁症状的严重程度。采用雙抗体夹心ABC-ELISA法检测所有受试者血浆IL-2、IL-6、IL-8、TNF-α浓度。根据CDSS评分将精神分裂症患者分为伴抑郁症状组（CDSS≥7分）和不伴抑郁症状组（CDSS7分）。分析促炎细胞因子水平与精神分裂症抑郁症状的相关性。 结果 精神分裂症患者血浆IL-6水平显著高于健康对照组（t=6.341，P0.001）;精神分裂症伴抑郁症状组PANSS总分、阴性症状因子分和一般精神病性症状因子分均高于不伴抑郁症状组（P0.05）。伴抑郁症状组血浆IL-6水平明显高于不伴抑郁症状组或健康对照组（Bonferroni校正后P0.001）;而不伴随抑郁症状组与对照组IL-6水平无显著差异（Bonferroni校正后P0.05）。相关性分析显示，精神分裂症患者血浆IL-6水平与抑郁症状呈明显正相关（r=0.294，P0.001）。结论 首发未服药精神分裂症患者外周高水平的IL-6与抑郁症状的发生有关。 [关键词] 精神分裂症;抑郁症状;细胞因子;白介素6 [中图分类号] R749.3 [文献标识码] A [文章编号] 1673-9701（2020）21-0006-05 Correlation between plasma IL-6 levels and depressive symptoms in unmedicated patients with first-episode schizophrenia YANG Jinling1 LIN Shuang1 CAO Yang2 LI Yaping3 LIU Lanying2 1.Department of General Internal Medicine， Zhejiang Provincial Tongde Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine， Zhejiang Institute of Traditional Chinese Medicine， Zhejiang Mental Health Center， Hangzhou 311100， China; 2.Department of Psychiatry， Zhejiang Provincial Tongde Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine， Zhejiang Institute of Traditional Chinese Medicine， Zhejiang Mental Health Center， Hangzhou 311100， China; 3.Department of Science and Education， Zhejiang Provincial Tongde Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine， Zhejiang Institute of Traditional Chinese Medicine， Hangzhou 311103， China [Abstract] Objective To investigate the relationship between the plasma proinflammatory cytokines interleukin-2（IL-2）， IL-6， IL-8 and TNF-α and the depressive symptoms in unmedicated patients with first-episode schizophrenia. Metho