血清肿瘤标志物联合检测对胃癌的诊断价值.docxVIP

血清肿瘤标志物联合检测对胃癌的诊断价值 孙会 祝丽晶 王正前 [摘要]目的 應用受试者工作特征（ROC）曲线评价几种血清肿瘤标志物联合检测对胃癌患者的诊断价值。方法 选取20XX年1月～20XX年12月我院收治的57例胃癌患者（A组）、50例胃良性病变患者（B组）、50例胃黏膜正常健康体检者（C组）作为研究对象，采用电化学发光法检测三组研究对象的血清癌胚抗原（CEA）、糖类抗原72-4（CA72-4）、糖类抗原50（CA50）、糖类抗原19-9（CA19-9）、糖类抗原242（CA242）水平并进行ROC分析。结果 A组的血清CEA、CA72-4、CA50、CA19-9、CA242表达水平均高于B组与C组，差异有统计学意义（P0.05）;随着胃癌分期的进展，胃癌患者血清中CEA、CA72-4、CA50、CA19-9、CA242的阳性检出率呈增长趋势。肿瘤标志物单独检测时，CA19-9的AUC最大，为0.777，CA72-4的检测敏感度最高，为77.7%;肿瘤标志物联合检测的诊断准确性提高，尤其是CA50、CA72-4、CA19-9和CA242联合检测时，AUC为0.925，敏感度提高至78.7%。结论 CA50、CA72-4、CA19-9和CA242联合检测能够有效提高胃癌患者诊断的准确性、敏感度，具有重要的临床诊断和应用价值。 [关键词]肿瘤标志物;联合检测;胃癌;受试者工作特征曲线 [中图分类号] R446 [文献标识码] A [文章编号] 1674-4721（2020）7（c）-0004-04 Diagnostic value of combined detection of serum tumor markers for gastric cancer SUN Hui1 ZHU Li-jing1 WANG Zheng-qian2▲ 1. Department of Clinical Laboratory， Lianshui People′s Hospital Affiliated to Kangda College of Nanjing Medical University， Jiangsu Province， Lianshui 223400， China; 2. MRI Room， Lianshui People′s Hospital Affiliated to Kangda College of Nanjing Medical University， Jiangsu Province， Lianshui 223400， China [Abstract] Objective To evaluate the diagnostic value of several serum tumor markers in patients with gastric cancer by using receiver operating characteristic （ROC） curve. Methods A total of 57 patients with gastric cancer （group A）， 50 patients with benign gastric lesions （group B） and 50 healthy patients with normal gastric mucosa （group C） from January 20XX to December 20XX in our hospital were selected as the research objects. Expression levels of carcino embryonic antigen （CEA）， carbohydrate antigen 72-4 （CA72-4）， carbohydrate antigen 50 （CA50）， carbohydrate antigen 19-9 （CA19-9） and carbohydrate antigen 242 （CA242） in serum for the three groups were detected by electrochemiluminescence. ROC curve was carried for analysis. Results The expression levels of CEA， CA72-4， CA50， CA19-9 and CA242 in group A patients were higher than those in group B and group