化学成分-半夏鱼腥草石油醚提取物的抗炎和镇痛作用(精).pdf

African Journal of Biotechnology Vol. 10(53, pp. 11023-11027, 14 September, 2011 Available online at /AJB ISSN 1684–5315 © 2011 Academic Journals Full Length Research Paper Chemical composition, anti-inflammatory and analgesic activities of the petrol ether extract of Pinellia cordata Baokang Huang1*, Zhiyong Chu2, Weiping He1 and Luping Qin1 1Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, China. 2Naval Medical Research Institute, Shanghai, China. Accepted 11 August, 2011 The analgesic and anti-inflammatory effect of the petrol ether extract of Pinellia cordata (PEPC was investigated using the xylene-induced ear edema and acetic acid- induced writhing test in mice. PEPC was administered intragastrically (i.g. at 200, 400 and 600 mg/kg. It had significant anti-inflammatory and analgesic activities with dose dependent manner. The chemical components of PEPC were analyzed by gas chromatography-mass spectrometry (GC/MS, and the main components were melissane (20.1%, τ-sitosterol (13.9% and linoleic acid (10.1%. These data may afford scientific basis on the traditional use of the plant for painful and inflammatory conditions. Key words: Anti-inflammatory, analgesic activity, Pinellia cordata , petrol ether extract, gas chromatography-mass spectrometry (GC/MS. INTRODUTION There are multiple reports of natural products having antimicrobial, anti- inflammatory and analgesic activities, and the essential oils, sesquiterpenes and flavonoids might be their active components (Akin et al., 2010; Lawal et al., 2010; Lu et al., 2009; Owolabi and Omogbai, 2007. In China, many traditional Chinese medicines have been used to treat pains or inflammation caused by conditions such as arthritis and tendinitis. Pinellia cordata is a medicinal plant (Araceae family native to southeast China. The plant is marked with arrowhead leaves and grows along fores