不对称二甲基精氨酸在冠心病临床分型中的应用.docVIP

不对称二甲基精氨酸在冠心病临床分型中的应用 中南大学学版)2o 1 o ,35(4) HYPERLINK http://xhyx.ysm.nelJChttp://xhyx.ysm.nelJC entSouthUnivMedSci) 301 Correlationbetweenplasmaasymmetricdimethylarginine anddifferenttypesofcoronaryheartdisease CAOYu,YANGKan,ZHANGZhihui,OUYANGMao,XIAOLi (DepartmentofCardiology,ThirdXiangyaHospital5CentralSouthUniversityChangsha41 0() 13,China) Abstract:ObjectiveTomonitorthechangesofplasmaasymmetricdiinethylarginine(ADM A), nitricoxide(NO),andvonWi!lebrandfactor(vWF)levelsinpatientswithstableanginapector is (SAP)oracutecoronarysyndrome(ACS)andtoevaluatethecorrelationbetweenADMAand different typesofcoronaryheartdisease.MethodsAtotalofl43subjectsweredividedintoanon 一 CHDgroup.a SAPgroupandanACSgro up.PlasmalevelsofADMA.NOandVWFwereexaminedanclthei rcorrela— tionwithSAPorACSwasanalyzed.ResultsComparedwiththenon — CHOortheSAPgroup,ADMA levelwaselevatedintheACSgroup(Plt;0.05).TheADMAleveltendedtoincreaseintheSA Pgroup comparedwiththenon 一 CHDgroup,buthadnosignificantdifference(Pgt;0.05).Comparedwiththe non CHDgro up,NOlevelwasdccrcasedinboththeSAPandACSgro up(P lt;0.05),anditdecrea sed moreinACSgroupthanthatintheSAPgroup(P lt;0?05);vwFlevelswereinoreasedinbothth eSAP andACSgroupcomparedwiththenon-CHDgroup(Plt;0.05).Therewasnosignificanuliff erencein theplasmalevelsofvWFintheSAPandtheACSgroup(Pgt;0.05).ConclusionThechangeo fplas— maADMAleveliscloselycorrelatedwithacutecoronarysyndrome.ADMAmightbeaclinic almarkerfor acutecoronarysyndrome. Keywords:asymmetricdimethylarginine;nitricoxide;coronaryheartdisease;acutecoro一 narysyndrome 不对称二甲基精氨酸在冠心病临床分型中的应用 曹宇，杨侃，张志辉,欧阳茂，肖丽 (中南大学湘雅三医院心血管内科，长沙410013) ［摘要］冃的:测定冠心病患者中稳定型心绞痛和急性冠脉综合征的血浆不对称二 甲基精氨酸 (ADMA)-氧化氮(NO)和血管性血友病因子(vWF)水平，探讨其与冠心病各临床 类型之间的关系. 方法:按纳入与排除标准入选了 143例研究对彖,其中包括非冠心病组64例，急性 冠脉综合征组54例 和稳定性心绞痛组25例?检测各组血浆ADMA,NO和vWF水平，并分析它们与急 性冠脉综合征和稳定 性心绞痛之间的相关性.结果:与非冠心病组和稳定型心绞痛组比较，急性尅脉综 合征血浆ADMA水 平显着升高(Plt;0.05).与非冠心病组相比,稳定型心绞痛组血浆ADMA水平有升 高趋势但差异无统 Dateofreception2009 06一-02 BiographyCAOYu,masterdegree,mainlyengagedintheinterventionalcard