β-内酰胺类抗菌药物的不良反应分析.docxVIP

袇282例B -内酰胺类抗菌药物的不良反应分析 For pers onal use only in study and research; not for commercial use 肅潘海燕，凌春燕，朱青（南京大学医学院附属鼓楼医院药剂科 ，南京市210008） 蚀 For pers onal use only in study and research; not for commercial use 芀摘要 目的：了解我院2009?2010年3 -内酰胺类抗菌药物药品不良反应 （ADR）发 生情况，分析其影响因素，以促进临床合理用药。方法：以我院2009?2010年上报告国家 药品不良反应监测中心的 282例3 -内酰胺类抗菌药物的 ADR为考察对象，分别从患者年龄、 性别、给药途径、使用药物种类以及临床表现等方面进行统计分析。 结果：ADR涉及3-内 酰胺类抗菌药物共 33种，以头孢曲松居首位，其次为头孢呋辛和氨曲南；以静脉途径给药 引发的ADR最多；282例ADR中 ,大于60岁的发生率最高，占28.72%;临床表现以皮肤及 其附件损害最常见。 结论：3 -内酰胺类抗菌药物发生 ADR与年龄、给药途径等多种因素相 关，应规范3 -内酰胺类抗菌药物的临床应用 ，避免或减少ADR的发生。 For pers onal use only in study and research; not for commercial use 腿关键词:3 -内酰胺类抗菌药物；药品不良反应；合理用药 袅 An alysis for 282 Cases of Adverse Drug React ion of 3 -lactam An tibiotics 蚂 Pan Haiya n , Ling Chunyan , Zhu Qi ng ( Dept.of Pharmacy, The Affiliated Drum Tower Hospital 莈 of Medical School of Nanji ng Un iversity , Nanji ng 210008) 薇 ABSTRACT Objective: To investigatethe reality and affecting 薇 ABSTRACT Objective: To investigate the reality and affecting factors of adverse drug react ions (ADR ) in duced by 3 -lactam an tibioticsin our hospital during adverse drug react ions (ADR ) in duced by 3 -lactam an tibiotics in our hospital during 2009~2010, in order to promote the proper use of drug in cli nic. Methods :We classifiedand analyzed 282 cases of adverse drug reactionof classified and analyzed 282 cases of adverse drug reaction of 3 -lactam antibiotics during 2009 during 2009?2010, according which is reported to National center for ADRMonitoring to the aspects of patients age and gender, admin istration route, species o f drugs and Clinical manifestations. Results: The ADRwere caused by a total of 33 species of 3 -lactam antibiotics agents, among which Ceftriaxone ranked the first and was followed by Cefuroxime and Aztreonam; The most causing route was intravenous administration; of which, those patients aged above 60 years accounted for 28.72%;the damageof skin and its annex were the most commonclinical manifest