动物生理学6.消化与吸收(四)..docxVIP

Pancreatic Secretion Composition and funtion of pancreatic juice Secretion of pancreatic juice is variable but averages about 2 litters daily in man, It has a pH of 7.6-8.2(alkaline) and contain s a high level of bicarbonates. The enzyme content of the juice is variable, depend on the stimulus, and ranges 0?1%~10% ? These enzymes include amylase淀粉酶、trypsin 胰伍 门酚, chymotrypsin 膜凝乳蛋 口酚,carboxypeptidase 氨妹肽酚， lipase 脂肪酶,etc. bioodsnwifnTU of pancreasIntertobwiar duaIntercalated duelIntralobular ductInterlobuiar dud1c pancpoWPancfeabc Met聞i Zs (secrete insulDuodenumHopaio pancreatc ampu4aMajor duodenalCtrciMor foklsHwd ol pancreasAc mi(Mcrolo on^ymes)Jejtnum bioodsnwifn TU of pancreas Intertobwiar dua Intercalated duel Intralobular duct Interlobuiar dud 1c pancpoW Pancfeabc Met 聞i Zs (secrete insul Duodenum Hopaio pancreatc ampu4a Major duodenal CtrciMor fokls Hwd ol pancreas Ac mi (Mcrolo on^ymes) Jejtnum Pancreanc duct duodenal 闻Ila Pancreatic amylase [ajmoJcis] 亠淀粉酚，不需要激活，可将淀粉、糖元等水解为糊精、 麦芽糖和麦芽寡糖，最适pH6.7?7.0 Trypsinogen and chymotrypsinogen trypsinogen trypsinChymotrypsinogen ■ trypsinogen trypsin Chymotrypsinogen ■ chymotrypsin procarbox y pe ptidase Pancreatic nuclease Pancreatic lipase Colipase is needed for lipase to hydrolyse triacylglyceride into fatty acids and glycerol. Colipase is a protein co-enzyme required for optimal enzyme activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin? Its function is to prevent the inhibitory effect of bile salts on the lipase- catalyzed inlraduodenal hydrolysis of dietary Iong-chain triglycerides. Regulation of pancreatic secretion Pancreatic secretion is under neural and humoral controL mainly the later? Nervous control Stimulation of vagus nerve causes small aiwunt of pancreatic juice, rich in enzymes. 属j:交感系的内脏人神经屮的胆碱能纤维促进胰液分泌， 但其中的忏上腺素能纤维抑制其分泌。 Humoral control Secretin （足｝庾液索 a hormone produced by the intestinal mucosa （小肠上