suc细胞信号通路ppt细胞信号通路大全上下细胞信号通路ppt fas_signaling.pptVIP

Fas Signaling Caspase2 PARP CytoC RAIDD TRAF1 DNA-PK MEK1 IKKs NF-kB Fas Daxx BTK FADD Ubc9 Sentrin Caspase7 Caspase10 Cleavage OfDeath Substrates DNAFragments Apoptosis PAK1/2 Apoptosis SMase Apoptosis Cell Proliferation Differentiation Ceramide Apoptosis CleavedICAD Lamin-A LaminB1 LaminB2 Apoptosis CAD APAF1 BID JNKK1 ASK1 Raf1 RIP2 Caspase8 Caspase3 D4-GDI DcR3 Fas ERK1 cIAP Caspase9 FLASH FAF1 Caspases1 JNKK1 JNK1 TRAF2 ProCaspase8 ERK Signaling c-Jun JNK1 NF-kB Pathway MEKK1 tBID Rb CAD CAD NIK c-FLIP 2009 ProteinL C * Review: Fas (also called Apo1 or CD95) is a death domain-containing member of the TNFR (Tumor Necrosis Factor Receptor) superfamily. It has a central role in the physiological regulation of Programmed Cell Death and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. Although the FasL (Fas Ligand)-Fas system has been appreciated mainly with respect to its death-inducing function, it also transduces proliferative and activating signals through pathways that are still poorly defined. The Fas Receptor induces an apoptotic signal by binding to FasL expressed on the surface of other cells. Fas is a Type-I transmembrane protein, where as FasL a Type-II Transmembrane protein of TNF family and can be shed in a soluble form by action of metalloproteinase (Ref.1). The Fas Receptor upon binding to the FasL trimerizes and induces Apoptosis through a cytoplasmic domain called DD (Death Domain) that interacts with signaling adaptors like FAF-1 (Fas-Associated Factor-1), FADD (Fas-Associated Death Domain), Daxx, FAP-1, FLASH (FLICE-associated huge) and RIP (Receptor-Interacting Protein). FADD carries a DED (Death Effector Domain) and by homologous interaction it recruits the DED containing Procaspase8 protein which is in inactive state. This protein complex is also known as DISC (Death-Inducing Signaling Pathways) and exists in Type-I cells. Procaspase8 is proteolytically activated to Caspase8.