药理学教学汕头大学药物代谢动力学.pptxVIP

药物代谢动力学Pharmacokinetics;学习目标;;为什么要知道药代动力学?;药动学内容;药物的跨膜转运(Drug Transport);转运模式;Mechanisms of drug permeation. Drugs may diffuse passively through aqueous channels in the intercellular junctions (eg, tight junctions, A), or through lipid cell membranes (B). Drugs with the appropriate characteristics may be transported by carriers into or out of cells (C). Very impermeant drugs may also bind to cell surface receptors (dark binding sites), be engulfed by the cell membrane (endocytosis), and then released inside the cell or expelled via the membrane-limited vesicles out of the cell into the extra