高等有机化学：第13章 线性自由能关系.pdfVIP

第13章 线性自由能关系 (Linear Free-Energy Relationships, LFERs ) O OH O O + H+ X X Qualitative Question: How does substituent X affect acidity? 1  e d O O c e Reminder n z a i l  n i  o b s a e t r s e Electron-donating groups d    decrease acidity + NH2 e  O O c d O O n e a z n i  l  o i s b e a r t s   NO2 NO2 induction stabilized Electron-withdrawing groups increase acidity 2 O OH O O Qualitative question: G + H+ How does substituent X affect K a