细胞信号通路ppt细胞信号通路上下细胞信号通路ppt remodeling_of_adherens_junctions.pptVIP

Dynamin E-Cadherin/Cdh1 P P E-Cadherin/Cdh1 E-Cadherin/Cdh1 E-Cadherin/Cdh1 Recycling and Degradation Depletion of Calcium NeighbouringCell Ubiquitination Junction Disassembly Junction Reassembly WEAKADHESION Plasmamembrane Plasmamembrane Remodeling of Adherens Junctions b-Ctnn p120Ctn a-Ctnn P P P Endocytosis b-Ctnn P b-Ctnn P P P P P b-Ctnn P P Loss of ActinCytoskeleton E-Cadherin/Cdh1 E-Cadherin/Cdh1 Removal ofUbiquitin Degradation ActinCoated Vacuolae (Phagosome) ClathrinCoatedVesicles EpithelialCell P Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub E2 Ub Ub Adherens JunctionFormation Recycling of E-Cadherin Hakai/E3 E1 Sec5 Zyx HGS Rab5 Hakai/E3 E1 E2 Rab7 P Rab11 Hakai Ub Ub Ub P E2 E1 Hakai/E3 E2 E1 Hakai/E3 Cdh1 Cdh1 Cdh1 Ub Ub P Cdh1 ARF6 GTP E2 E1 Hakai/E3 Nm23H1 ARF6 GDP Vcl F-Actin Vcl Deubiquitination Recycling E2 E1 Hakai/E3 a-Ctnn 26SProteasome RalA Caveolin RalA-Exocyst Complex ARF6 GTP Cdh1 Cdh1 Cdh1 Cdh1 Cdh1 ARP2/3 ARP2/3 Lysosome Lysosomal Degradation of E-Cadherin Clathrin MT-BPs a-Actn a-Actn Tubulin Sorting APC CLIP170 Zyx Degradedb-Ctnn and E-Cadherin P PTKs Src P P Met P IQGAP1 Dubs LateEndosome EarlyEndosome RecyclingEndosome CaveolinCoatedVesicles Dubs HGF 2009 ProteinL C * Review: The intercellular Adherens Junctions (AJs) are specialized sub-apical structures that function as principle mediators of cell-cell adhesion. Their disassembly correlates with a loss of cell-cell contact and an acquisition of migratory potential. The Adherens Junctions have a crucial role both as sensors of extracellular stimuli and in regulating the dynamics of epithelial cell sheets or with neighboring cells. Cadherins, the Type-I transmembrane proteins of the Adherens Junctions, are principally responsible for homotypic cell-cell adhesion. E-Cadherin, which is present primarily in epithelia, is the best-characterized Cadherin and represents the prototype of classical Cadherins. The extracellular doma