课件参考讲义大一下课件易静cell and death.ppt

* * * * * * * * * 全反式维甲酸诱导细胞分化用于白血病治疗 上海第二医科大学 1995年 未知： 诱导肿瘤细胞或肿瘤干细胞重新分化的因子及其组合 ？ Cell Death No death without life Apoptosis: programmed death, suicide necrosis: accidental, murdered But… 细胞死亡 (Cell death) 细胞凋亡和坏死 细胞死亡有两种形式：细胞凋亡和细胞坏死 细胞凋亡（apoptosis): apoptosis为希腊语，原指秋天时树叶自然凋零。细胞凋亡指细胞在一定的生理和病理条件下，遵循自身的程序，自己结束生命的过程。 细胞坏死(necrosis): 外来致病因素作用下使得细胞正常代谢活动被强行中断而引起的“意外”的、被动性死亡过程；只见于病理情况下。 textbook 细胞坏死necrosis 细胞凋亡apoptosis The biological significances of apoptosis 1. Development (embryo, postnatal) 2. Tissue homeostasis (epithelia, blood, immune) 3. Damage repair 4. Senescence To eliminate senescent cells to reduce the risk of cancer development 2002年因对细胞凋亡研究的杰出贡献获得诺贝尔奖 The first division of two of the ventral cord neuroblasts, viewed by Nomarski optics in a living animal. Cell lineages of the ventral cord. [Sulston and Horvitz, 1977] 由此得出结论： 线虫发育过程中共产生过1090个细胞，131个细胞通过凋亡被除去.留存959个细胞。 一些基因的表达控制了细胞凋亡是否发生 Cells decrease their number by apoptosis. Two pathways for apoptosis （1）death receptor （2）mitochondrion Activating platform for procaspase9 –work of Wang Xiaodong Survival vs apoptosis： Cells require survival signals to avoid apoptosis Growth factor signaling: to live or die Apoptotic cell ? via mitochondrial pathway （animation） 三氧化二砷诱导细胞凋亡用于白血病治疗 上海第二医科大学 1997年 Cancer Biol Ther. 2002 Nov-Dec;1(6):614-20. Treatment of acute promyelocytic leukemia with ATRA and As2O3: a model of molecular target-based cancer therapy. Fang J, Chen SJ, Tong JH, Wang ZG, Chen GQ, Chen Z. Shanghai Institute of Hematology, Ruijin Hospital affiliated to Shanghai Second Medical University, Shanghai, P. R. China. * * * * * * * * * * * Cells increase their number by cell division. How do they increase their types? How do they become another type by changing their structures and functions? Total cell number：1014 Total cell types：200 Embryonic development  Cell Differentiation The process by which a less specialized ce