药物性肝损伤引起的肝内胆汁淤积症.pptxVIP

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药物性肝损伤引起的肝内胆汁淤积症.pptx

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Intrahepatic cholestasis due to drug-induced liver injury (DILI);;CONTENTS;A: Introduction;Definitions epidemiology;cholestasis;Intrahepatic vs Extrahepatic Cholestasis;Intrahepatic vs Extrahepatic Cholestasis;DILI: drug-induced liver injury;Epidemiology of DILI;B: Pathophysiology;complex pathology in dili;Models of dili pathology;Drugs most commonly involved as causes of DILI in a prospective cohort;DILI Clinical Consortia: A global research response for a worldwide health challenge;pattern of injury;Two main patterns of DILI;Diagnosis of DILI pattern;the most common pattern is Hepatocellular;Most common or well-described DILI agents and patterns of liver injury;Most common or well-described DILI agents and patterns of liver injury;Cancer therapy-induced dili;Cancer therapy-induced dili;Host demographic, clinical and laboratory features affect outcome;C: Diagnosis management;Diagnosis;Diagnosis of Drug-Related Hepatotoxicity;Diagnosis of Drug-Related Hepatotoxicity;Management;Management of dili;MEDICAL INTERVENTION;D: Ademetionine;Mechanism of action;Ademetionine in health and dili;Ademetionine mechanism of action;WHAT IS Ademetionine AND What does IT, as a methyl donor, do?;Ademetionine: Potential Mechanisms of Action;Clinical efficacy;Overview of studies of ademetionine;Gorbakov 1998;Gorbakov 1998;Gorbakov 1998;Gorbakov 1998;Gorbakov 1998;Gorbakov 1998;Zhdanov 2009;Zhdanov 2009;Zhdanov 2009;Neri 2002;Neri 2002;Neri 2002;Neri 2002;Perlamutrov 2014;Perlamutrov 2014;Perlamutrov 2014;Perlamutrov 2014;Perlamutrov 2014;Santini 2003;Santini 2003;Santini 2003;Kazyulin 2010;Kazyulin 2010;Vincenzi 2011;Vincenzi 2011;Vincenzi 2011;Vincenzi 2011;Vincenzi 2012;Vincenzi 2012;Vincenzi 2012;Vincenzi 2012;Larionova 2015 ;Larionova 2015;Larionova 2015;D: CONCLUSIONS;dili is common with no specific therapy yet available;ademetionine for the treatment of IHC due to dili