chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism,fibrosis,oxida.chicoric酸减弱非酒精性脂肪肝炎通过抑制脂类代谢的主要.pdfVIP

Page 1 Molecular Nutrition Food Research Molecular Nutrition and Food Research Research Article Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation and inflammation in mice with methionine and choline deficiency Running title: Chicoric acid inhibits nonalcoholic steatohepatitis Myungsuk Kim1,2, GyHye Yoo1,2, Ahmad Randy1,3, Hyoung Seok Kim1,2, and Chu Won Nho1,2* 1 Natural Products Research Center, Korea Institute of Science and Technology, Gangneung, Republic of Korea 2 Convergence Research Center for Smart Farm Solution, Korea Institute of Science and Technology, Gangneung, Republic of Korea Received: 21/07/2016; Revised: 29/11/2016; Accepted: 05/12/2016 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/mnfr.201600632. This article is protected by copyright. All rights reserved. Page 2 Molecular Nutrition Food Research 3 Department of Biological Chemistry, Korea, University of Science and Technology, Daejeon, Republic of Korea * Correspondence : Chu Won Nho, Head, Convergence Research Center for Smart Farm Solution, Korea Institute of Science and Technology Gangneung Institute, 679 Saimdang- ro, Gangneung, Gangwon-do, Republic of Korea Phone: 82-33-650-3651, Fax: 82-33-650-3679, E-mail: cwnho@kist.re.kr (C.W. Nho). Abbreviations: CDE, Crepidiastrum denticulatum extract; NAFLD, non-alcoholic fatty liver disease; NAS, NAFLD activity score; NASH, non-alcoholic steatohepatitis; MCD, methionine and choline deficient; TC, total cholesterol; TG, triglycerides; AMPK, AMP kinase; ALT, alanine aminotransferase; AST, aspartate am