帕金森病治疗（77页）.ppt

Oral levodopa L-dopa infusion Plasma levodopaconcentration (ng/mL) 0 1000 2000 3000 4000 5000 4 10 6 12 8 2 Time (hours) Enteral infusion reverses motor complications by avoiding deep troughs in plasma levodopa levels 0 OFF-time (hours/day) Dyskinesia score (AIMS) 1 2 3 4 5 6 7 8 9 * p0.001 AIMS=Abnormal Involuntary Movement Score * * Deep troughs in plasma L-dopa Stocchi et al. Arch Neurol 2005;62(6):905 After 6 months’ treatment (n=6) L-dopa methylester infusion 250 mg/ml12 hs at initial rate of 125 mg/h (n=1) Avoiding deep troughs is key to avoiding motor complications Levodopa infusi