健脾除湿疏利少阳法治疗慢性肾小球肾炎的临床分析.docxVIP

中文摘要 试验目的：初步评价健脾除湿、疏利少阳法治疗慢性肾小球肾炎的有效性和安全性。 方法：木文通过具有健脾除湿、疏利少阳作用的慢肾安颗粒与肾炎平颗粒进行随机对 照临床研究，初步探讨健脾除湿、疏利少阳法治疗慢性肾小球肾炎的有效性和安全性。 结果:FAS分析结果表明，慢肾安颗粒试验组对慢性肾小球肾炎的临床控制率为14. 0% , 控显率为36. 4%,总有效率为65. 5%；肾炎平颗粒对照组分别为20. 0%、40. 0%和70. 0%, 组间比较，差异无统计学意义。慢肾安颗粒试验组对患者脾虚湿盛的愈显率为36. 5%, 总有效率为84. 5%；肾炎平颗粒对照组分别为25.0%和68.4%,组间比较，差异无统计 学意义。慢肾安颗粒试验组对患者蛋白尿的临床控制率为15.5%,控显率为41.4%,总 有效率为60. 3%；肾炎平颗粒对照组分别为25.0%、36. 8%和68. 4%,组间比较，差异 无统计学意义。慢肾安颗粒试验组对患者血尿的临床控制率为34. 1%,控显率为34. 1%, 总有效率为43.2%；肾炎平颗粒对照组分别为45.5%、45.5%和54. 5%,组间比较，差 异无统计学意义。两组治疗前后均进行了三大常规、肝功、心电图及电解质检查，均 未发现与试验药物有关的界常改变，试验过程中未见明显不良反应，安全性较好。 结论：健脾除湿、疏利少阳法是治疗慢性肾小球肾炎的有效治法之一,能较好的改善 患者的临床症状，减少蛋白尿和血尿，稳定肾功能。 关键词：健脾除湿 疏利少阳 慢性肾小球肾炎 中医药疗法 临床研究 ABSTRACTS Objective： To study the effect and safety of TCM therapy(named by reiforce the spleen and transforming dampness 、 smoothing and regulating shao?yang) on chronic glomerulonephritis. Methods : To study the effect and safety of TCM therapy(named by reiforce the spleen and transforming dampness 、 smoothing and regulating shao-yang) on chronic glomerulonephritis. The study adopts clinic method of random and comparison through Manshenan granule and Shenyanping granule which have the function of reiforce the spleen and transforming dampness smoothing and regulating shao-yang. hat conform to the condition can be selected. Giveing the pationts medicine according to sequence of patients coming to hospital and arrange the pationt to the group of cure or the group of comparison. The result of FAS shows: in the group of chronic glomerulonephritis that is treated,the rate of complete remission is 14.0%,cure and great efficiency is 36.4%,total efficiency is65.5%.in the group of comparison, the rate of complete remission is 20.0%,cure and great efficiency is 40.0%,total efficiency is 70.0%.The group comparison indicates: the contrast has no statistically significant. In the group of damp abundance due to splenic asthenia that is treated, the rate of cure and great efficiency is 36.5%, total efficiency is84.5 %, in the