新辅助化疗并术中125I植入治疗Ⅲ期膀胱癌的临床分析（肿瘤学范文）.docVIP

新辅助化疗并术中125I植入治疗Ⅲ期膀胱癌的临床分析（肿瘤学范文） 文档信息 属性： F-00XK6N，doc格式，正文7103字。质优实惠，欢迎下载！ 适用： 作为文章写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 作者： 佚名 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 搞要 1 关键字：膀胱肿瘤；125I粒子；安全性；毒性 2 1 资料与方法 3 2 结果 5 3 讨论 6 [参考文献] 7 论文原创声明（模板） 9 论文致谢（模板） 10 正文 新辅助化疗并术中125I植入治疗Ⅲ期膀胱癌的临床分析（肿瘤学范文） 搞要 摘要：目的探讨新辅助化疗并术中125I植入治疗Ⅲ期膀胱癌的短期疗效与安全性。方法42例初治Ⅲ期膀胱癌患者随机分为研究组（19例）和对照组（23例），研究组患者接受GC方案静脉化疗1个周期，15d后进行根治性膀胱切除术，并对残余及可疑病灶植入放射性125I粒子，对照组的23例患者仅接受1个周期GC方案静脉化疗及根治性膀胱切除术治疗。结果随访期内（6～12个月）两组均无患者死亡。研究组无患者出现局部复发，肿瘤复发率0%（0/19），无远处转移患者（0/19）；对照组6例出现局部复发，肿瘤复发率%（6/23），远处转移率%（2/23），差异有统计学意义（均P）。两组不良事件的发生率相当（P）。结论新辅助化疗并术中125I植入治疗Ⅲ期膀胱癌是一种安全、有效的治疗方式，具有良好的短期疗效 关键字：膀胱肿瘤；125I粒子；安全性；毒性 [中图分类号] [文献标识码] B [文章编号] 1673-9701（2016）24-0084-03 [Abstract] Objective To investigate the short-term effect and safety of neoadjuvant chemotherapy combined with intraoperative 125I implantation in the treatment of bladder cancer of stage Ⅲ. Methods A total of 42 initially treated patients with bladder cancer of stage Ⅲ were randomly divided into study group （19 cases） and control group （23 cases）. Intravenous chemotherapy with GC scheme for 1 period was given to the patients of study group and radical cystectomy was performed after 15 days and 125I particles were implanted into the residual and suspected lesions. Intravenous chemotherapy with GC scheme for 1 period and radical cystectomy was given to the 23 patients of control group. Results No death of the patients was presented during the follow-up period （6-12 months）. The rate of local recurrence and tumor recurrence of the patients form study group was 0%（0/19） and no distant metastasis （0/19）； while local recurrence and tumor recurrence were presented in 6 patients of the control group with the rate of %（6/23） and the distant metastatic rate was % （2/23）. The differences was statistically significant （both P）. The incidence rate of adverse events of both group was similar（P）. Conclusion Neoadjuvant chemotherapy combined with intra